Surgery revealed a follicular carcinoma arising in a struma ovarii. If you log out, you will be required to enter your username and password the next time you visit. [Medline]. Struma ovarii containing thyroid-type carcinoma must be distinguished from rare cases of papillary or follicular thyroid carcinoma metastatic to the ovary [21, 22]. . Jeannie Chen Kelly, MD Resident Physician, Department of Obstetrics and Gynecology, Tufts Medical CenterDisclosure: Nothing to disclose. Llueca A, Maazouzi Y, Herraiz JL, Medina MC, Piquer D, Segarra B, et al. }. Three months post-operatively, she remained thyrotoxic despite stopping thyroxine. This data will be updated every 24 hours. 2003 Sep. 28 (9):725-7. The overall 5-, 10-, and 20-year survival rates in the study were 96.7%, 94.3%, and 84.9%, respectively, with only one of the deaths that occurred being attributed to malignant struma ovarii. } It represents about 0.01% of overall ovarian tumours and 5 to 10% of struma ovarii. All these signs are nonspecific and overlap with those caused by an ovarian malignancy. Struma ovarii is a monodermal variant of ovarian teratoma, which was initially described by Bottlin in 1888 and, later, by Pick in 1902 and 1903, who recognized that struma ovarii was composed of thyroid tissue.1 Malignancy of struma ovarii is rare. Abstract. Case presentation: A 17-year-old patient was diagnosed with papillary thyroid cancer in struma ovarii. It is rare for struma ovarii to present with features of hyperthyroidism. David Chelmow, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Medical Association, American Society for Colposcopy and Cervical Pathology, Association of Professors of Gynecology and Obstetrics, Council of University Chairs of Obstetrics and Gynecology, Phi Beta Kappa, Sigma Xi, The Scientific Research Honor Society, Society for Academic Specialists in General Obstetrics and Gynecology, Society for Reproductive InvestigationDisclosure: Nothing to disclose. "metricsAbstractViews": false, Jordan G Pritzker, MD, MBA, FACOG Adjunct Professor of Obstetrics/Gynecology, Hofstra North Shore-LIJ School of Medicine at Hofstra University; Attending Physician, Department of Obstetrics and Gynecology, Long Island Jewish Medical Center; Medical Director, Aetna, Inc; Private Practice in GynecologyDisclosure: Nothing to disclose. [Medline]. A goitre can be associated with a thyroid that is not functioning properly. Malignant struma ovarii presenting with follicular carcinoma is extremely rare, and its mechanism of tumorigenesis remains unknown. Struma ovarii—a kind of teratoma; Thyroid hormone receptor; References External links. Med Ultrason. PURPOSE: To present a case of struma ovarii with a typical features and synchronous primary thyroid carcinoma and review the available literature to guide diagnosis and management of these tumors. Serra, Anna Metastasis to the ovary from primary thyroid carcinoma can be ruled out by clinical thyroid examination and ultrasonography. It is rare for struma ovarii to … The most common thyroid-type malignancies to arise in struma ovarii are papillary and follicular carcinomas. It most commonly occurs as part of a teratoma, but may occasionally be encountered with serous or mucinous cystadenomas. Thyroid. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjU2OTM3LW92ZXJ2aWV3. Gynecol Oncol. Struma ovarii means ovarian goiter which originates from a Jung SI, Kim YJ, Lee MW, Jeon HJ, Choi JS, Moon MH. It often presents with nonspecific symptoms and can mimic ovarian malignancy. Like the cervical thyroid gland, this ectopic thyroid tissue can become autonomous. 2014 Nov 6. Mui MP, Tam KF, Tam FK, Ngan HY. The malignant struma ovarii was first described by Wetteland in 1956. We present a case of hyperthyroidism caused by thyroid tissue in a large ovarian cystic teratoma and provide detailed endocrinological, radiological, and pathological preoperative and postoperative data. Struma ovarii is a rare ovarian tumor defined by the presence of thyroid tissue comprising more than 50% of the overall mass. Struma ovarii is a rare ovarian tumour that has been reported to represent 0.5%–1.0% of all ovarian tumours. 255771-overview The common presentation is abdominal, with pelvic mass and pain, traditionally managed by gynaecologists. Struma ovarii is a specialized or monodermal teratoma predominantly composed of mature thyroid tissue . [Medline]. 2017. Feature Flags: { Struma ovarii (SO) is a slow-growing ovarian neoplasm with thyroid tissue as its predominant component. It is important to consider struma ovarii in a woman with a proposed laparotomy because a thyroid crisis can be precipitated following the surgical procedure. Medina, Mari Carmen "relatedCommentaries": true, Struma ovarii is an uncommon type of ovarian mature teratoma with a predominant thyroid component. [Medline]. Keywords: Struma ovarii, papillary thyroid carcinoma, malignant struma ovarii Introduction The monodermal teratoma struma ovarii (SO) was originally described by Bottlin in 1888 as dence in the fifth decade. Thyroid. [Medline]. Struma ovarii - ultrasound features of a rare tumor mimicking ovarian cancer. 2019. 2018 Aug 30. These two cases highlight the diagnostic and therapeutic role of thyroid surgeons in the management of benign and malignant forms of struma ovarii. 2009 Mar. When hyperthyroidism is caused by an ectopic thyroid … Rarely, struma ovarii undergoes malignant transformation. Worldwide, over 90% of goitre cases are caused by iodine deficiency. Several variants of the tumor exist. The common presentation is abdominal, with pelvic mass and pain, traditionally managed by gynaecologists. Struma ovarii is an infrequent type of dermoid ovarian tumor that is usually benign and composed of at least 50% thyroid tissue. Struma ovarii usually refers to the presence of significant amount of thyroid tissue in ovarian tumors, typically monodermal teratomas. Michel E Rivlin, MD is a member of the following medical societies: American College of Obstetricians and Gynecologists, American Medical Association, Mississippi State Medical Association, Royal College of Surgeons of Edinburgh, Royal College of Obstetricians and GynaecologistsDisclosure: Nothing to disclose. Goffredo P, Sawka AM, Pura J, et al. Struma Ovarii. Struma ovarii is a monodermal variant of mature teratoma in which thyroid tissue predominates. The incidence of malignancy arising in patients with struma ovarii is rare. Struma ovarii is a monodermal variant of ovarian teratoma, which was initially described by Bottlin in 1888 and, later, by Pick in 1902 and 1903, who recognized that struma ovarii was composed of thyroid tissue.1 Malignancy of struma ovarii is rare. Metastasis to the ovary from primary thyroid carcinoma can be ruled out by clinical thyroid examination and ultrasonography. "metrics": true, In these cases, the ovarian masses are bilateral and have no teratomatous features Histological analysis of the resected ovary showed benign struma ovarii. Gynecol Oncol. Render date: 2021-01-07T22:03:42.841Z It is defined by the presence of thyroid tissue comprising more than 50% of the overall mass. Close this message to accept cookies or find out how to manage your cookie settings. (1) Malignancy of struma ovarii is rare. Struma ovarii and peritoneal strumosis with thyrotoxicosis. The immense majority are benign, and ~5% are malignant [ 1 ]. Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumor, derivate from monodermic teratomas. Malignant struma ovarii (MSO) includes tumor types seen in the eutopic thyroid, such as papillary thyroid carcinoma (both the classical type and the follicular variant) and follicular carcinoma. The common presentation is abdominal, with pelvic mass and pain, traditionally managed by gynaecologists. Thyroid tissue is either the major constituent or is the cause of thyrotoxicosis in 2‑4% of teratomata (2). Struma ovarii is a rare form of ovarian neoplasm in a form of mature teratoma and is composed predominantly of thyroid tissue. Malignant Struma Ovarii: A Population-Level Analysis of a Large Series of 68 Patients. Int J Gynecol Pathol. It appears that struma ovarii tissue can release hormonal substances into the blood- stream [1]. Malignant struma ovarii presenting with follicular carcinoma is extremely rare, and its mechanism of tumorigenesis remains unknown. Hence, the detection of this protein in serum would reflect recurrent or residual tumor. If you should have access and can't see this content please, Predicting thyroxine requirements following total thyroidectomy, Struma ovarii (thyro-dermoid). Shaco-Levy R, Peng RY, Snyder MJ, Osmond GW, Veras E, Bean SM, et al. 2004 Sep. 94(3):835-9. Riedel's struma Riedel's thyroiditis . Struma ovarii is a teratoma of the ovaries that contains a large amount of thyroid tissue. It was found that 6% a rare form of ovarian tumor. [5]. Barengolts, Elena Awareness of these possibilities facilitates postoperative care in these patients. Struma ovarii is a rare form of teratoma characterised predominantly (>50%) of thyroid tissue in the ovary.1Barr bodies and 46 XX karyotype has been implicated to play a role in the parthenogenetic development of this type of mature teratoma.6Its malignant conversion to thyroid-type carcinoma has been associated with BRAF mutation similar to that observed in the carcinoma of the … [Medline]. Abdom Imaging. 2017. Ovarian teratoma either composed predominantly or exclusively of benign thyroid tissue or with any amount of malignant thyroid tissue Most common thyroid malignancy to occur in struma ovarii is papillary thyroid carcinoma, followed by follicular carcinoma A 53-year-old woman with left adnexial mass underwent total abdominal hysterectomy with bilateral salpingo-oopherectomy. [Medline]. Defined as a tumor of ovarian origin, struma ovarii occurs exclusively in genetic females. Case Discussion. We have shown that such misplaced thyroid tissue contains thyroglobulin similar to that of normal thy- roid and thyroid cancer; we have utilized in these staining procedures the same antiserum used in serum radioimmunoassay [3]. Is Use of Powder in Genital Area a Risk for Ovarian Cancer? We present a case of hyperthyroidism caused by thyroid tissue in a large ovarian cystic teratoma and provide detailed endocrinological, radiological, and pathological preoperative and postoperative data. The term is from the Latin gutturia, meaning throat. David Chelmow, MD Leo J Dunn Professor and Chair, Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center Struma ovarii accounts for only 2 % of all mature teratomas, and less than 5 % of struma ovarii present malignant trans-formation [4, 6, 7]. [Medline]. The malignant form is extremely rare and consists of differentiated thyroid cancer. [1 ] Struma ovarii were first described in 1899 and comprise 1% of all ovarian tumors. Here, we present a case of malignant struma ovarii with peritoneal dissemination of follicular carcinoma, for which a molecular analysis for major oncogenic gene alterations in follicular thyroid carcinoma was performed. and Maazouzi, Yasmine The malignant form is extremely rare and consists of differentiated thyroid cancer. The diagnosis is histologic and retrospective after pelvic surgery; radiographic imaging being unspecific. Struma ovarii is a rare ovarian tumor that was first described in 1899. 89(3):543-8. It represents about 0.01% of overall ovarian tumours, and 5 to 10% of struma ovarii. It is usually diagnosed postoperatively, and its histopathological diagnostic criteria remain identical to that of papillary carcinoma of the thyroid gland. [Medline]. Bal A, Mohan H, Singh SB, Sehgal A. Malignant transformation in mature cystic teratoma of the ovary: report of five cases and review of the literature. In the literature review, there has only been 10 cases of this tumor, associated with ascites and pleural effusion (Meig's Syndrome) and increased CA125 so far. Llueca, Antoni Postoperatively, she was diagnosed with a malignant struma ovarii. We present two unusual cases of struma ovarii and discuss the role of the thyroid surgeon in their management. Abdominal hysterectomy revealed two abdominal masses that were consistent with thyroid tissue at histopathological examination. However, the possibility exists that, in the female patient, ovarian thyroid tissue may be present, may produce thyroglobulin, and may lead to a misdiagno- sis of recurrent thyroid cancer. Struma ovarii is a rare, monodermal, ovarian teratoma. The simultaneous presence of thyroid carcinoma in the struma ovarii and the thyroid gland is extremely rare. Thyroid tissue must comprise more than 50 percent of the overall tissue to be classified as a struma ovarii. Shulan, Joseph Clinical characteristics of struma ovarii. 19(3):305-8. Struma ovarii is ectopic thyroid tissue associated with dermoid tumors or ovarian teratomas that can secrete excessive amounts of thyroid hormone and produce thyrotoxicosis. Struma ovarii is a rare ovarian tumor that was first described in 1899. [ 18 ] … Wolsky, Rebecca J. Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views. Le struma ovarii malin de type carcinome folliculaire est rare, seule l'analyse immunohistochimique permet d’en affirmer la nature. 2003 Jun. The patient exhibited menstrual disorders. This is the first study by collecting all Chinese cases with clinical information. Roth LM, Talerman A. and Struma ovarii is an uncommon condition, in which thyroid tissue is the predominant or exclusive element in an ovarian teratoma. Alvarez, Edwin A. Mengesha, Biftu M. All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. Because of its rarity, no clear racial predilection for struma ovarii has been determined. Thus, 10% of ovarian tumors are teratomas and 2-4% of them may be called "struma ovarii", but those with associated thyrotoxicosis are extremely rare. It most commonly occurs as part of a teratoma.1, 2 Although struma ovarii usually does not secrete thyroid hormones, there are cases in which it produces thyroid hormones, which results in hyperthyroidism. Bassols, Guillermo First described by Von Klden in 1895 and Gottschalk in 1899, struma ovarii is the most common type of monodermal teratoma, and comprises about 3.0% of all ovarian teratomas. Garzon, Steven PATIENT FINDINGS: We report a patient with Graves' disease and unilateral benign functioning struma ovarii, accompanied by ascites, pleural effusion and elevated cancer antigen-125 (CA-125) levels. Shen J, Xia X, Lin Y, Zhu W, Yuan J. The second case involved a 60-year-old woman who underwent thyroidectomy for thyrotoxicosis. "openAccess": "0", Segarra, Blanca Due to difficulties in assessing the rare biological nature and the discrepancies in the reported cases, a consensus on the appropriate treatment has not been definitively reached. Papillary thyroid carcinoma (PTC) arising in a coexistent struma ovarii (SO) is a rare malignancy. Struma ovarii is diagnosed when thyroid tissue comprises more than 50 % of the teratoma [4, 5]. 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